Rent A Car and Drive From Chicago to St. Louis

Are you looking to go to St. Louis? In these uncertain times, many of us are rethinking the way we travel and the added safety precautions that must be considered along the way. A rental car from a neighborhood Enterprise location in Chicago can alleviate many of these concerns, so you can get to St. Louis safely.  
Drive time: approx. 4.5 hour (Driving Directions)

Distance: approx. 298 miles

COVID-19 Car Rental Resources


From our Complete Clean Pledge to curbside pickup options, we're here to help you get back on the road again. 

COVID-19 Car Rental FAQs

Check our COVID-19 FAQs for information on hours of operation, reservations and steps we're taking to keep employees and customers safe.


Planning a Road Trip During COVID-19

Are you thinking about taking a road trip during COVID-19? Check out our tips and resources to consider before you leave.

Plan Your Trip

Complete Clean Pledge

Learn about our commitment to protecting the well-being of customers and employees, including our Complete Clean Pledge.

Complete Clean Pledge Details

Chicago Drives and Road Trips

Popular Rental Vehicle Types


Our SUVs offer flexibility with seating capacity, power, and luggage room. Find the ideal SUV for your next weekend family trip or exploring the countryside.
Rent an SUV


Looking to haul large items for DIY projects or going on a weekend retreat? A pickup truck has space, power and durability ideal for your project or trip.
Rent a Truck


Need extra room for people, luggage, or cargo or both? Our minivans and passenger vans can seat up to 7 and 15 people and are great for family vacations or large groups.
Rent a Van