Enterprise
Truck Rentals

Pickup Truck Rental in St. Louis

If you need to move furniture or haul supplies, renting a pickup truck through Enterprise will make the process much easier. We have trucks of various sizes to best suit your needs. Reserve a truck online for our lowest rates. 

Explore Rental Pickup Trucks

Don't see the vehicle your looking for?  View all Trucks

FAQs for Renting Trucks in St. Louis

Yes, all of our pickup trucks can be rented one way. This option is great if you are moving small items a few hours away or taking a cross-state road trip with rugged terrain. A drop charge may apply for one-way rentals, which will be disclosed at the time of reservation. 

Trucks are not available by the hour, but Enterprise does rent out trucks by the day. This gives you the flexibility to use the truck for several hours or a full day. We offer great rates and our easy rental process will get you on the road quickly. 

Although pickup trucks from our Enterprise Rent-A-Car fleet cannot be used to tow, you can go through Enterprise Truck Rental to do so. The Enterprise Truck division offers 3/4 ton pickup trucks and 1-ton pickup trucks that can be used to tow boats, campers, and more. 

Popular Road Trips from St. Louis

St. Louis is your gateway to scenic drives across the Midwest, with easy access to open highways and rolling landscapes. Whether you’re planning a quick getaway or a longer adventure, these routes from St. Louis provide a mix of small-town charm, cultural attractions, and plenty of opportunities to explore along the way.

chicago skyline

St. Louis to Chicago

296 mi (4 hr 28 min)

Head north on I-55 and enjoy a drive through Illinois farmland and small towns before reaching Chicago’s vibrant skyline. Once there, explore Millennium Park, stroll the Magnificent Mile, and take in views from the Willis Tower Skydeck.

kansas city skyline

Drive From St. Louis to Kansas City

248 mi (3 hr 40 min)

Travel west on I-70 through Missouri’s rolling hills and charming towns. Kansas City welcomes you with world-famous barbecue, a thriving arts scene, and attractions like the Nelson-Atkins Museum of Art and the lively Power & Light District.

springfield il

St. Louis to Springfield, IL

98 mi (1 hr 35 min)

The short trip north on I-55 offers a smooth ride through Illinois countryside. Springfield is steeped in Abraham Lincoln’s legacy, with landmarks like the Lincoln Home and Presidential Library, plus classic Midwestern dining.

ozarks

St. Louis to Lake of the Ozarks

180 mi (2 hr 51 min)

Head west from St. Louis on I-70 and US-54, passing through Missouri’s rolling hills and scenic countryside. The Lake of the Ozarks is a popular getaway for boating, fishing, and waterfront dining, with plenty of trails and coves to explore.

indianapolis

St. Louis to Indianapolis

243 mi (3 hr 41 min)

Heading east on I-70, the route to Indianapolis passes through rural landscapes and small towns. Once there, visit the Indianapolis Motor Speedway, explore cultural districts, and enjoy local dining in the heart of the city.

nashville

St. Louis to Nashville

307 mi (4 hr 30 min)

Drive southeast through Illinois and Kentucky before arriving in Music City. Nashville offers legendary live music venues, the Country Music Hall of Fame, and a vibrant downtown filled with entertainment and dining

One-Way Car Rental

Looking to rent a car for a one-way trip? Enterprise Rent-A-Car offers convenient one-way car rentals. We have a great selection of vehicles for trips across the city, across the country or from the airport.

One-Way Car Rental

Long-Term Car Rental

This is ideal for corporate relocations, temporary work assignments, extended trips, and much more. It can also be used while waiting for a new fleet car. 

Long-Term Car Rental