Drive From St. Louis to Indianapolis
Are you looking to take a road trip? A rental car from your local neighborhood Enterprise location might be the best option for your travel! Enterprise offers quick, convenient travel options so you can get on the road faster. With so many styles and options available, you’re sure to find the perfect rental car for your travels.
Drive time: approx. 3.75 hours (Driving Directions)
Distance: approx. 250 miles
Benefits of Renting a Car
- Reduce wear-and-tear and/or mileage on your own vehicle
- Choose from a variety of rental cars – like compacts, minivans or luxury SUVs – to fit your group’s needs
- Select a style with extra cargo space – perfect for camping gear, hiking equipment or that last-minute RSVP
- Enjoy add-ons such as car seats, GPS/navigational systems, ski racks and more
Popular Road Trip Cars
Take your pick from one of these classic road trip car options.
St. Louis Drives and Road Trips
- Rent a Car & Drive From Chicago to St. Louis
- Rent a Car & Drive From St. Louis to Chicago
- Rent a Car & Drive From St. Louis to Milwaukee
- Rent a Car & Drive From St. Louis to Pensacola
- Rent a Car & Drive From St. Louis to Nashville
- Rent a Car & Drive From St. Louis to Kansas City
- Rent a Car & Drive From St. Louis to Little Rock
- Rent a Car & Drive From St. Louis to the Ozarks
- Rent a Car & Drive From St. Louis to Indianapolis