Drive from San Francisco to Portland on Highway 101

Portland, Oregon, is a popular destination for fun activities that range from the Portland Art Museum to the 189-acre Hoyt Arboretum and everything in between. With impeccable food, a stellar beer and wine scene, scenic views and outdoor adventures around every corner, Portland is a perfect place to visit for every lifestyle. Whether you're taking a vacation of many West Coast highlights, or you're a San Francisco native looking for a scenic road trip, you'll find the route from San Francisco to Portland on US-101 is both beautiful and intriguing. Pack up the family in a reliable, rugged vehicle and take on the fanciful forests, breathtaking coast, and quaint towns along this route. For a quicker, more direct route, you can take I-5 the entire way. Before you head out make sure you are prepared for the open road with our checklist of road trip essentials.

Drive Time from San Francisco to Portland: approximately 14 hours
Distance from San Francisco to Portland:  approximately 715 miles
Best car for this road trip: SUV


Start Your Trip

Start A Reservation

Enjoy fast and easy car rental bookings from Enterprise Rent-A-Car at one of our 7,200 branches in cities, airports and neighborhoods near you.

Reserve Now

Email Offers

Don't miss an excuse to hit the road: our latest offers delivered to your inbox.

Sign Up